The 46-year-old was found at her home on Monday, according to TMZ .
The American comedian and actress told the website: “I am saddened to hear about this terrible tragedy. Mental illness is a very serious issue affecting many families. My thoughts and prayers go out to Michelle’s family, her wife and their child.”
Rosie and Michelle had started dating in 2011 and married in a private ceremony in 2012.
The two wed in a private ceremony in New York on June 9, 2012. Rounds underwent surgery to remove desmoid tumors only five days later. It marked second marriage for O’Donnell, who has four children, ages 4 through 22, with Kelli Carpenter.